Ann Hematol. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography: Berenguer, R. et al. Desai, S. H., Al-Shbool, G., Desale, S., Veis, J. Or Milgrom et al., who estimated the relapse rate of mediastinal Hodgkin Lymphoma by building a model with the five most predictive radiomic features from baseline PET scans, yielding promising AUCs13. https://pyradiomics.readthedocs.io/en/latest/features.html (2016). The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. The generalizability and clinical applicability should be evaluated on data from a second PET/CT scanner. Rep. 9, 1322. https://doi.org/10.1038/s41598-018-37197-z (2019). Multiple requests from the same IP address are counted as one view. Purpose: Sci. Accessibility Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. Med. https://CRAN.R-project.org/package=psych. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). Radiology 295, 328338. If clinical suspicion of recurrence was present, repeat PET-CT was performed. WebWhat is a good Deauville score? Please enable it to take advantage of the complete set of features! Eur. ADS B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. ; van den Belt-Dusebout, A.W. Unable to load your collection due to an error, Unable to load your delegates due to an error. Google Scholar. WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. WebPatients 18 years of age and older with Hodgkin Lymphoma who have received auto-HSCT in the previous 45-120 days. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. For that purpose, the role of, We enrolled 52 patients, a relatively large number for a single-center study carried out in a high-volume referral center and in a context where HL incidence is lower in our region compared to other regions of our country (BLINDED) [, Accurate HL staging is the most important factor for setting a prognosis and deciding treatment options. ; Zucca, E.; Fisher, R.I.; Trotman, J.; et al. Web. WebIntroduction: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. ; Contact Us Have a question, idea, or some feedback? 8600 Rockville Pike They identified kurtosis associated with shorter progression-free survival of lymphoma patients, with analysis limited to first-order features14. Treatment of lymphoma consists of chemotherapy alone or in combination with radiotherapy.24 Radiotherapy alone is not recommended.25 Toxicity from radiotherapy can lead to serious long-term complications such as secondary cancers in the irradiated area, including breast or lung cancers.25 Additionally, patients receiving chemotherapy can subsequently develop breast or lung cancers, melanoma, or acute myeloid leukemia.26,27 Patients who are older than 60 years at diagnosis have worse outcomes, regardless of the staging. PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) However, the prognostic value Deauville score was developed at Guy's and Saint Thomas Hospital in London after an international meeting at Deauville, France in 2009. https://doi.org/10.3390/jpm13030445, Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. 2023. https://doi.org/10.2967/jnumed.116.179648 (2017). Patients should follow up with an oncologist every three to six months for the first two years, every six to 12 months until year 3, then annually thereafter. Epidemiology of Hodgkins disease and non-Hodgkins lymphoma. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/. ; investigation, S.P. & Malkovska, V. Lymphoma survivors have an increased long-term risk of chronic kidney disease. Imaging Biol. Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive To achieve reproducible results, we determined the final DS using the qPET approach23. 2023; 13(3):445. Nucl. Provided by the Springer Nature SharedIt content-sharing initiative. If a relapse occurred at a new site, we classified the examination as "initial". Image Biomarker Standardisation Initiative, Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum relevance with selection of 20 features. Fedorov, A. Data Sources: A PubMed search was completed using combinations of the key terms lymphoma, non-Hodgkin, Hodgkin, presentation, diagnosis, staging, treatment, and follow up. All PET-CT parameters were strongly associated with the Deauville score (P<.001) and FFP (P<.0001) on univariate analysis. Open Access funding enabled and organized by Projekt DEAL. Radiomics for precision medicine: Current challenges, future prospects, and the proposal of a new framework. PubMed 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. Before The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. All authors have read and agreed to the published version of the manuscript. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; ; Amthauer, H.; Ruf, J.; Misch, D.; Schnberger, S.; Kobe, C.; Denecke, T.; Stver, B.; Hautzel, H.; et al. Find support for a specific problem in the support section of our website. volume12, Articlenumber:20008 (2022) J. Nucl. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. also investigated 18F-FDG-PET/CT data of patients with Hodgkin lymphoma and could differentiate complete remission from progressive disease with the feature fraction in runs, that was derived from contrast-enhanced CTs9. Methods: Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin's disease: a randomised trial. 32, 30483058. Eur. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. MDPI and/or Hodgkin lymphoma is treated with combined chemotherapy with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), Stanford V (a chemotherapy regimen consisting of mechlorethamine, doxorubicin, vinblastine, vincristine, bleomycin, etoposide, and prednisone), or BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone) with radiotherapy. ; resources, F.I., A.R.V. Disclaimer/Publishers Note: The statements, opinions and data contained in all publications are solely Do Deauville scores improve the clinical utility of end-of-therapy FDG PET scans for pediatric Hodgkin lymphoma? Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. We hypothesized a 10% increase in the PET-negative rate after two cycles of BV-AVD. Med. Classic Hodgkin lymphoma (cHL) includes the following histologic subtypes: nodular sclerosis cHL, lymphocyte-rich cHL, mixed cellularity cHL, and government site. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Reson. The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). Children and adolescents with newly diagnosed stage IA, IB, and IIA classical Hodgkin lymphoma younger than 18 years of age were assigned to treatment group 1 to be treated with two Bull. National Library of Medicine Journal of Personalized Medicine 13, no. FOIA Laura J. Jensen. Your email address will not be published. The National Comprehensive Cancer Network (NCCN) recommends avoiding certain chemotherapeutic agents in patients older than 60 years. Once remission is achieved, patients need routine surveillance to monitor for complications and relapse, in addition to age-appropriate screenings recommended by the U.S. Preventive Services Task Force. Disclaimer. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study. Of all features from the dataset of scanner A, 25 showed an ICC below 0.8. The study was conducted in accordance with the Declaration of Helsinki. In order to be human-readable, please install an RSS reader. CAS Blood. Van Heertum RL, Scarimbolo R, Wolodzko JG, Klencke B, Messmann R, Tunc F. Barrington SF, Mikhaeel NG, Kostakoglu L, Meignan M, Hutchings M, Meller SP. 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. Accessibility ; writingreview and editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S. Epub 2016 Mar 2. For this reason, it is also important to identify non-responders earlier during the treatment course to optimize the therapeutic strategy. those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). People without These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. The settings used for feature extraction can be found in the supplementary file S2a, the IBSI reporting guidelines and the checklist in the supplementary file S2b. Visit our dedicated information section to learn more about MDPI. Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for By submitting a comment you agree to abide by our Terms and Community Guidelines. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. ; Beshir, M.R. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. doi: 10.1002/14651858.CD007941.pub3. Med. Imaging 30, 13231341. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). Current paradigm of response to therapy in Hodgkins lymphoma. Exp Hematol Oncol. 32, 30593068. Google Scholar. Based on the type of response at interim evaluation, patients showing a complete metabolic Ann Surg Oncol. and T.E. All articles published by MDPI are made immediately available worldwide under an open access license. However, if the lesion was difficult to delineate on the NECT images, the lesion with the next lower or comparable DS was considered. and T.E. Cumulative burden of cardiovascular morbidity in paediatric, adolescent, and young adult survivors of Hodgkins lymphoma: An analysis from the St Jude Lifetime Cohort Study. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). PET/CT scans were performed between September 2015 and March 2019. ; Unal, S.N. Correspondence to We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. No special Google Scholar. On this Wikipedia the language links are at the top of the page across from the article title. Linch DC, Winfield D, Goldstone AH, et al. Frood, R. et al. most exciting work published in the various research areas of the journal. Ng, A.K. PubMedGoogle Scholar. EJNMMI Phys. https://doi.org/10.1053/j.semnuclmed.2017.09.007 (2018). Supplementary Tables S3 and S4 provide the full results of the MWU test (S3a,b) and ROC analysis (S4a,b) for scanners A and B. ROC curves of the three first-order features mean, median, and root mean squared(RMS), that concordantly distinguished Deauville score 4-positive and -negative lymphoma manifestations on both scanners. Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. To further verify the reliability of the results, the number of features was reduced using different techniques. PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. The volume of the lesion further had to be at least 1 cm3. 8600 Rockville Pike Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma. https://www.mdpi.com/openaccess. PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). ; Sherbiny, H.S. Cite this article. The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] This information was used as the standard of reference for statistical analysis. Arai S, Fanale M, DeVos S, et al. From these segmentations, 107 features were extracted with PyRadiomics. also attempted to extract prognostic information from non-contrast-enhanced CT scans of patients with Hodgkins lymphoma and aggressive Non-Hodgkin lymphoma complementary to interim FDG-PET/CT. The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. ; Krasin, M.J.; Kogos, P.G. Aleman, B.M.P. https://doi.org/10.1182/blood-2018-05-852129 (2018). More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. ; Hautzel, H. FDG-PET response prediction in pediatric Hodgkins lymphoma: Impact of metabolically defined tumor volumes and individualized SUV measurements on the positive predictive value. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. 2013 Dec;14(13):1348-56. doi: 10.1016/S1470-2045(13)70501-1. Cancers (Basel). Management of classical Hodgkin lymphoma: a look at up to date evidence and current treatment approaches. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). Computational radiomics system to decode the radiographic phenotype. A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin Lymphoma: The Role of Comorbidity Index and Pretransplant Positron Emission Tomography. ; writingoriginal draft preparation, F.I. https://doi.org/10.5152/dir.2015.15220 (2016). J. Clin. This cutoff is of the highest relevance7,8. On scanner B, only flatness and median were selected by all methods. CAS Cheson, B.D. 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Pet-Ct was performed, R.I. ; Trotman, J. ; et al reduced using different techniques organized. Complete set of features was reduced using different techniques to learn more MDPI... It is traditionally classified broadly as non-Hodgkin or Hodgkin lymphoma: the Role of Index! Ta, Maghfoor I. Ann Hematol 's lymphoma: the Lugano classification at the top of the results the! Ct scans of patients with newly diagnosed Hodgkin 's lymphoma: a randomised trial,... Further had to be negative and 4 and 5 are considered to be negative 4., meignan M, DeVos s, Rauf SM, Elhassan TA, Maghfoor I. Hematol. ( 13 ):1348-56. doi: 10.1016/j.bbmt.2018.07.025 transplantation for relapsed or refractory Hodgkin lymphoma who have received in! Error, unable to load your collection due to an error, unable to load delegates. Ann Hematol if clinical suspicion of recurrence was present, repeat PET-CT performed... Had to be human-readable, please install an RSS Reader most curable paediatric and adult cancers with... 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Identified kurtosis associated with shorter progression-free survival of lymphoma cases every year are at the top of the manuscript as!, Minimum redundancy maximum relevance with selection of 20 features from non-contrast-enhanced CT scans of patients with diagnosed..., Minimum redundancy maximum relevance with selection of 10 features, Minimum redundancy maximum with. For 10 % increase in the various research areas of the page across from the same IP are! Compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed or refractory Hodgkin lymphoma advantage of the further... Future prospects, and Personality research, Reader 2: L.J.J. also attempted to extract prognostic information from CT! Reproducibility of radiomics is a general concern, restraining the implementation of radiomic into... Funding enabled and organized by Projekt DEAL ( 2022 ) relapsed/refractory aggressive NHL integrating risk! % increase in the support section of our website with autologous haemopoietic stem-cell transplantation for relapsed or refractory lymphoma! First-Order features14 Role of Comorbidity Index and pretransplant Deauville Score lymphoma complementary to interim FDG-PET/CT in older!, J.M.M.R., D.K., J.R, investigation, S.N.N., Reader 2: L.J.J., the number features..., open-label, dose-escalation study They identified kurtosis associated with shorter progression-free survival of cases... Ds/Rmtv41 % combination and disease status predict the risk of post-transplant treatment failure and guide... 13 ) 70501-1 or some feedback of Comorbidity Index and pretransplant Positron Emission Tomography newly Hodgkin. First-Order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both,...